Article
Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features.
Nature communications - 25 Jan 2021
Mendelaar Pauline A J, Smid Marcel, van Riet Job, Angus Lindsay, Labots Mariette, Steeghs Neeltje, Hendriks Mathijs P, Cirkel Geert A, van Rooijen Johan M, Ten Tije Albert J, Lolkema Martijn P, Cuppen Edwin, Sleijfer Stefan, Martens John W M, Wilting Saskia M
Abstract excerpt
In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of metastasized CRC. Here we present whole genome sequencing data of metastases of 429 CRC patients participating in the pan-cancer CPCT-02 study (NCT01855477). Unsupervised clustering using mutational signature patterns highlights three major patient groups characterized by signatures known from primary CRC, signatures...
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