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Article

Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor.

The Journal of biological chemistry - 22 Jun 2012

Wang Jingyi, Papke Roger L, Stokes Clare, Horenstein Nicole A

Abstract excerpt

A series of arylidene anabaseines were synthesized to probe the functional impact of hydrogen bonding on human α7 nicotinic acetylcholine receptor (nAChR) activation and desensitization. The aryl groups were either hydrogen bond acceptors (furans), donors (pyrroles), or neither (thiophenes). Thes...

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Identifiers

PMID: 22556416
DOI: 10.1074/jbc.M112.339796
PMCID: PMC3381156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22556416-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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