Article
[Analysis of IDH1 and IDH2 mutations in patients with acute myeloid leukemia].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 May 2012
Jia Zhu-xia, Zhou Min, Chao Hong-ying, Lu Xu-zhang, Zhang Ri, Cen Ling, Xiao Rong, Jiang Nai-ke
Abstract excerpt
OBJECTIVE: To explore the prevalence of IDH gene (IDH1 and IDH2) mutations, types of mutations in patients with acute myeloid leukemia (AML), correlation with the internal tandem duplication(ITD) mutation of FLT3 gene, NPM1 gene mutation and some clinical characteristics. METHODS: The mutations of IDH1 and IDH2 gene at exon 4, NPM1 gene at exon 12 and FLT3-ITD at exon 14 and 15 in 163 newly diagnosed AML patients...
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