Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Journal of medicinal chemistry - 9 Aug 2012

Qin Zhihui, Luo Jia, VandeVrede Lawren, Tavassoli Ehsan, Fa' Mauro, Teich Andrew F, Arancio Ottavio, Thatcher Gregory R J

Abstract excerpt

Learning and memory deficits in Alzheimer's disease (AD) result from synaptic failure and neuronal loss, the latter caused in part by excitotoxicity and oxidative stress. A therapeutic approach is described that uses NO-chimeras directed at restoration of both synaptic function and neuroprotectio...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Avoidance Learning
Share to Biological Availability
Share to Molecular Mimicry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuroprotective Agents

Share to Primary Cell Culture

Share to Prodrugs

Share to Receptors, GABA-A

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 22779770
DOI: 10.1021/jm300353r
PMCID: PMC3680370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22779770-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.PMID 22779770Read ↗

NO Chimeras as Therapeutic Agents in Alzheimers DiseaseSemantic proximity Read ↗

Morphing Cholinesterase Inhibitor Amiridine into Multipotent Drugs for the Treatment of Alzheimer's DiseaseSemantic proximity Read ↗

Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studiesSemantic proximity Read ↗

The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and RegenerationSemantic proximity Read ↗

The NTR/Prodrug Revolution: Tools for Controlling Cell Loss and RegenerationSemantic proximity Read ↗

Chromone and donepezil hybrids as new multipotent cholinesterase and monoamine oxidase inhibitors for the potential treatment of Alzheimer's diseaseSemantic proximity Read ↗

Inducing BDNF and mTOR-Mediated Synaptogenesis via Oral Agents: A Hypothetical Prophylaxis for Alzheimer’s DiseaseSemantic proximity Read ↗

Exploring N(1)-p-fluorobenzyl-cymserine as an inhibitor of 5-lipoxygenase as a candidate for type 2 diabetes and neurodegenerative disorder treatment.Semantic proximity Read ↗

Attenuation of Reactive Astrogliosis Accompanies Neurological Recovery Induced by Novel Poly-Target 2,3-Benzodiazepines After Experimental Traumatic Brain InjurySemantic proximity Read ↗

Minocycline Attenuates Neuronal Cell Death and Improves Cognitive Impairment in Alzheimer's Disease ModelsSemantic proximity Read ↗

Novel thiazolidinedione hybrids as cholinesterase inhibitors and targeting neuroblastoma: design, synthesis, in vitro and in silico biological evaluationsSemantic proximity Read ↗

Synthesis of novel hybrids of 1,2,3-triazoles-hydrazone: targeting cholinesterases and Alzheimer's related genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.