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Article

NO Chimeras as Therapeutic Agents in Alzheimers Disease

17 Jun 2006

Abstract excerpt

NO is an important messenger molecule in the brain, playing an important role in learning and memory, in particular via the ERK/CREB signaling pathway. NO is also a neuroprotective agent; multiple mechanisms having been demonstrated that can contribute to cell survival as levels of antioxidants and trophic factors are reduced with aging. Small molecules that mimic the biological activity of NO, including NO...

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PMID: 16842101
DOI: 10.2174/156720506777632925

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