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Article

A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.

The Journal of biological chemistry - 5 Feb 2010

Holst Birgitte, Nygaard Rie, Valentin-Hansen Louise, Bach Anders, Engelstoft Maja S, Petersen Pia S, Frimurer Thomas M, Schwartz Thue W

Abstract excerpt

The conserved tryptophan in position 13 of TM-VI (Trp-VI:13 or Trp-6.48) of the CWXP motif located at the bottom of the main ligand-binding pocket in TM-VI is believed to function as a rotameric microswitch in the activation process of seven-transmembrane (7TM) receptors. Molecular dynamics simul...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19920139
DOI: 10.1074/jbc.M109.064725
PMCID: PMC2823539

Genes

GPR39

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19920139-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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