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Article

Molecular mechanism of plasmid-borne resistance to sulfonamides

2022-06-30

Abstract excerpt

The sulfonamides (sulfas) are the oldest class of synthetic antibacterial that target the essential, conserved dihydropteroate synthase (DHPS) enzyme, encoded by folP , through chemical mimicry of its substrate p -aminobenzoic acid ( p ABA). Resistance has complicated their clinical utility and is widespread in pathogenic species. Resistance is mediated by acquisition of sul genes on mobile genetic elements, w...

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Literature Corpus work
c98d7f0a-5153-59c3-997c-30fa8ca2a960
DOI
10.1101/2022.06.30.498311
Open publication

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Molecular mechanism of plasmid-borne resistance to sulfonamidesDOI 10.1101/2022.06.30.498311
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