Article
Hypercholesterolemia promotes an osteoporotic phenotype.
The American journal of pathology - 1 Sept 2012
Pelton Kristine, Krieder Jaclynn, Joiner Danese, Freeman Michael R, Goldstein Steven A, Solomon Keith R
Abstract excerpt
A role for hypercholesterolemia in the development of osteoporosis has been suggested in published reports. However, few studies contain direct evidence of a role for maintenance of cholesterol homeostasis in bone health. Using isocaloric high-fat/high-cholesterol and low-fat/no-cholesterol diets in a 4-month feeding study combined with micro computed tomography analysis, we demonstrated in two different mouse...
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