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Article

Hyperlipidemia Promotes Osteoclastic Potential of Bone Marrow Cells Ex Vivo

16 Dec 2003

Abstract excerpt

OBJECTIVE: Osteoporosis is associated epidemiologically with atherosclerosis and hyperlipidemia. We previously found that atherogenic lipids regulate bone formation. To determine whether hyperlipidemia also affects bone resorption, we compared osteoclastogenesis in marrow preosteoclasts derived from hyperlipidemic versus control mice. METHODS: Nonadherent marrow cells from low-density lipoprotein receptor-/-...

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PMID: 14670933
DOI: 10.1161/01.atv.0000112023.62695.7f

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