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Article

High resolution discrimination of clinical Mycobacterium tuberculosis complex strains based on single nucleotide polymorphisms.

PloS one - 1 Jan 2012

Homolka Susanne, Projahn Michaela, Feuerriegel Silke, Ubben Tanja, Diel Roland, Nübel Ulrich, Niemann Stefan

Abstract excerpt

Recently, the diversity of the Mycobacterium tuberculosis complex (MTBC) population structure has been described in detail. Based on geographical separation and specific host pathogen co-evolution shaping MTBC virulence traits, at least 20 major lineages/genotypes have evolved finally leading to a clear influence of strain genetic background on transmissibility, clinical presentation/outcome, and resistance...

Topics

Algorithms
Animals
Evolution, Molecular
Genes, Bacterial
Genotyping Techniques
Host-Pathogen Interactions
Humans
Mycobacterium tuberculosis
Polymorphism, Single Nucleotide
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tuberculosis

Virulence Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22768315
DOI: 10.1371/journal.pone.0039855
PMCID: PMC3388094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22768315-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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