Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress.

The European journal of neuroscience - 1 Mar 2012

Rieker Claus, Schober Andreas, Bilbao Ainhoa, Schütz Günther, Parkitna Jan Rodriguez

Abstract excerpt

The high susceptibility of dopaminergic (DA) neurons to cellular stress is regarded as a primary cause of Parkinson's disease. Here we investigate the role of the serum response factor (SRF), an important regulator of anti-apoptotic responses, for the survival of DA neurons in mice. We show that loss of SRF in DA neurons does not affect their viability and does not influence dopamine-dependent behaviors. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Oxidative Stress

Share to Parkinsonian Disorders

Share to Serum Response Factor

Share to Substantia Nigra

Source

Identifiers

PMID: 22356487
DOI: 10.1111/j.1460-9568.2012.08003.x

Genes

SRF
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ablation of serum response factor in dopaminergic neurons exacerbates susceptibility towards MPTP-induced oxidative stress.PMID 22356487Read ↗

Pro-Survival Role for Parkinson's Associated Gene DJ-1 Revealed in Trophically Impaired Dopaminergic NeuronsSemantic proximity Read ↗

Death in the substantia nigra: a motor tragedySemantic proximity Read ↗

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP.Semantic proximity Read ↗

Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonismSemantic proximity Read ↗

Neuroprotection and dopamine agonistsSemantic proximity Read ↗

Dissociation of Progressive Dopaminergic Neuronal Death and Behavioral Impairments by Bax Deletion in a Mouse Model of Parkinson's DiseasesSemantic proximity Read ↗

ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats.Semantic proximity Read ↗

The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic InterventionSemantic proximity Read ↗

miR‐34a/BCL‐2 signaling axis contributes to apoptosis in MPP+‐induced SH‐SY5Y cellsSemantic proximity Read ↗

ALCAR promote adult hippocampal neurogenesis by regulating cell-survival and cell death-related signals in rat model of Parkinson's disease like-phenotypes.Semantic proximity Read ↗

Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.Semantic proximity Read ↗

Parkinson's Disease-Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.