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Identification of the actinorhodin monomer and its related compound from a deletion mutant of the actVA-ORF4 gene of Streptomyces coelicolor A3(2).

Bioorganic & medicinal chemistry letters - 1 Aug 2012

Taguchi Takaaki, Ebihara Takayuki, Furukawa Atsushi, Hidaka Yumiko, Ariga Ryuji, Okamoto Susumu, Ichinose Koji

Abstract excerpt

An oxygenated derivative of dihydrokalafungin (DHK) was isolated from a deletion mutant of the actVA-ORF4 gene involved in the biosynthesis of a dimeric benzoisochromanequinone (BIQ) antibiotic, actinorhodin (ACT), in Streptomyces coelicolor A3(2). Spectroscopic analysis elucidated its structure as 8-hydroxy-DHK, corresponding to the monomeric unit of ACT. Further metabolite analysis identified its related...

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PMID: 22765902
DOI: 10.1016/j.bmcl.2012.06.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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