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Article

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice.

Hepatology (Baltimore, Md.) - 1 Mar 2012

Heymann Felix, Hammerich Linda, Storch Dunja, Bartneck Matthias, Huss Sebastian, Rüsseler Vanessa, Gassler Nikolaus, Lira Sergio A, Luedde Tom, Trautwein Christian, Tacke Frank

Abstract excerpt

UNLABELLED: Chemokines critically control the infiltration of immune cells upon liver injury, thereby promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect trafficking of monocytes/macrophages, monocyte-derived dendritic cells (DCs) and T-helper cell (Th) subsets, but its role in liver diseases is currently unknown. To investigate the functional role of CCR8 in liver diseases,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22031018
DOI: 10.1002/hep.24764
PMCID: PMC4533854

Genes

CCR8
CCL1
CCL3
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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