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Article

Association of the TYMS 3G/3G genotype with poor response and GGH 354GG genotype with the bone marrow toxicity of the methotrexate in RA patients.

European journal of clinical pharmacology - 1 Mar 2013

Jekic Biljana, Lukovic Ljiljana, Bunjevacki Vera, Milic Vera, Novakovic Ivana, Damnjanovic Tatjana, Milasin Jelena, Popovic Branka, Maksimovic Nela, Damjanov Nemanja, Radunovic Goran, Kovacevic Ljiljana, Krajinovic Maja

Abstract excerpt

PURPOSE: Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action. In a group of 184 RA patients treated with MTX, we have investigated whether selected polymorphisms in these genes modulate MTX efficacy an...

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Source

Identifiers

PMID: 22763757
DOI: 10.1007/s00228-012-1341-3

Genes

GGH
TYMS
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22763757-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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