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Article

Association of dihydrofolate reductase (DHFR) -317AA genotype with poor response to methotrexate in patients with rheumatoid arthritis.

Clinical and experimental rheumatology - 1 Jan 2000

Milic Vera, Jekic Biljana, Lukovic Ljiljana, Bunjevacki Vera, Milasin Jelena, Novakovic Ivana, Damnjanovic Tatjana, Popovic Branka, Maksimovic Nela, Damjanov Nemanja, Radunovic Goran, Pejnovic Nada, Krajinovic Maja

Abstract excerpt

OBJECTIVES: Identifying genetic predictors of methotrexate (MTX) treatment response in patients with rheumatoid arthritis (RA) may have great importance for optimising drug doses required for clinical benefit without toxicity. In a group of 125 RA patients treated with MTX we investigated whether selected polymorphisms in genes relevant for MTX action (aminoimidazole-4-carboxiamide ribonucleotide transformylase,...

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Identifiers

PMID: 22324981

Genes

DHFR
ATIC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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