Article
Genetic polymorphisms associated with therapeutic response and adverse effects to methotrexate in Taiwanese patients with rheumatoid arthritis: a real-world, hospital-based study.
Scientific reports - 9 Jun 2026
Yu Ta-Wei, Chen I-Chieh, Lin Guan-Cheng, Kao Chung-Mao, Chen Yen-Ju, Chen Yi-Ming
Abstract excerpt
Although methotrexate (MTX) is extensively utilized in management of rheumatoid arthritis (RA), its pharmacogenomics are still unclear. This study explores the genetic determinants impacting MTX's effectiveness and adverse effects in Taiwanese patients with RA, aiming to enhance understanding of RA treatment and pharmacogenetics. A retrospective analysis of 1,948 RA patients receiving MTX treatment from January...
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