Article
Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria.
Cytobios - 1 Jan 1990
Dudani A K, Austin R C, Venner T J, Gupta R S
Abstract excerpt
Using antibodies to a mitochondrial molecular chaperone class of protein, which is specifically altered in mutants resistant to microtubule (MT) inhibitors, the effect of a number of MT and mitochondrial inhibitors on the cellular distribution of mitochondria and various cytoskeletal filaments was examined. Treatment of Chinese hamster ovary (CHO) or chicken embryo fibroblast (CEF) cells with the MT inhibitors...
Topics
- Animals
- Antineoplastic Agents
- Cell Line
- Chick Embryo
- Colchicine
- Fluorescent Antibody Technique
- Guinea Pigs
- Microtubules
- Mitochondria
- Mutation
- Nocodazole
- Podophyllotoxin