Modifications of microfilaments and microtubules induced by two hepatic tumor promoters, phenobarbital and biliverdin in non-transformed and transformed hepatic cell lines.

doi:10.1007/BF00135024

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Article

Modifications of microfilaments and microtubules induced by two hepatic tumor promoters, phenobarbital and biliverdin in non-transformed and transformed hepatic cell lines.

Cell biology and toxicology - 1 Jan 1990

Decloitre F, Lafarge-Frayssinet C, Martin M, Frayssinet C

Abstract excerpt

Microfilaments and microtubules are components of the cytoskeleton which could be implicated in neoplastic transformation. We studied the effect of two hepatic tumor promoters, phenobarbital (PB) and biliverdin (BV), on microfilaments and microtubules of non-transformed (Cl3) and transformed (FV) hepatic epithelial cells. Cl3 non-transformed cells cultured in the presence of 1 X 10(-6) M BV for 48 h showed a loss...

Topics

Actin Cytoskeleton
Actins
Animals
Bilirubin
Biliverdine
Cell Line
Cell Line, Transformed
Cell Transformation, Neoplastic
Cytoskeleton
Dimethyl Sulfoxide
Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Microtubules

Phenobarbital

Phenotype

Rats

Rhodamines

Tubulin

Source

Open in PubMed

Identifiers

PMID: 1970750
DOI: 10.1007/BF00135024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1970750-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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