Article
Removal of MAP4 from microtubules in vivo produces no observable phenotype at the cellular level.
The Journal of cell biology - 1 Feb 1996
Wang X M, Peloquin J G, Zhai Y, Bulinski J C, Borisy G G
Abstract excerpt
Microtubule-associated protein 4 (MAP4) promotes MT assembly in vitro and is localized along MTs in vivo. These results and the fact that MAP4 is the major MAP in nonneuronal cells suggest that MAP4's normal functions may include the stabilization of MTs in situ. To understand MAP4 function in vivo, we produced a blocking antibody (Ab) to prevent MAP4 binding to MTs. The COOH-terminal MT binding domain of MAP4...
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