Article
Increased volatile anesthetic requirement in short-sleeping Drosophila mutants.
Anesthesiology - 1 Feb 2009
Weber Bernd, Schaper Christian, Bushey Daniel, Rohlfs Marko, Steinfath Markus, Tononi Giulio, Cirelli Chiara, Scholz Jens, Bein Berthold
Abstract excerpt
BACKGROUND: Anesthesia and sleep share physiologic and behavioral similarities. The anesthetic requirement of the recently identified Drosophila mutant minisleeper and other Drosophila mutants was investigated. METHODS: Sleep and wakefulness were determined by measuring activity of individual wild-type and mutant flies. Based on the response of the flies at different concentrations of the volatile anesthetics...
Topics
- Alleles
- Anesthetics, Inhalation
- Animals
- Dose-Response Relationship, Drug
- Drosophila
- Female
- Isoflurane
- Male
- Motor Activity
- Mutation
- Sleep