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Article

NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells.

Cancer research - 15 Aug 2012

Yap Kai Lee, Fraley Stephanie I, Thiaville Michelle M, Jinawath Natini, Nakayama Kentaro, Wang Jianlong, Wang Tian-Li, Wirtz Denis, Shih Ie-Ming

Abstract excerpt

NAC1 is a transcriptional corepressor protein that is essential to sustain cancer cell proliferation and migration. However, the underlying molecular mechanisms of NAC1 function in cancer cells remain unknown. In this study, we show that NAC1 functions as an actin monomer-binding protein. The conserved BTB protein interaction domain in NAC1 is the minimal region for actin binding. Disrupting NAC1 complex function...

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Identifiers

PMID: 22761335
DOI: 10.1158/0008-5472.CAN-12-0302
PMCID: PMC3421062

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