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Article

Tumor suppressor activity of profilin requires a functional actin binding site.

Molecular biology of the cell - 1 Apr 2004

Wittenmayer Nina, Jandrig Burkhard, Rothkegel Martin, Schlüter Kathrin, Arnold Wolfgang, Haensch Wolfgang, Scherneck Siegfried, Jockusch Brigitte M

Abstract excerpt

Profilin 1 (PFN1) is a regulator of the microfilament system and is involved in various signaling pathways. It interacts with many cytoplasmic and nuclear ligands. The importance of PFN1 for human tissue differentiation has been demonstrated by the findings that human cancer cells, expressing conspicuously low PFN1 levels, adopt a nontumorigenic phenotype upon raising their PFN1 level. In the present study, we...

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Source

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Identifiers

PMID: 14767055
DOI: 10.1091/mbc.e03-12-0873
PMCID: PMC379259

Genes

PFN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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