Article
The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.
Diabetes care - 1 Sept 2012
Florez Jose C, Jablonski Kathleen A, Taylor Andrew, Mather Kieren, Horton Edward, White Neil H, Barrett-Connor Elizabeth, Knowler William C, Shuldiner Alan R, Pollin Toni I
Abstract excerpt
OBJECTIVE: The C allele at the rs11212617 polymorphism in the ataxia-telangiectasia-mutated (ATM) gene has been associated with greater clinical response to metformin in people with type 2 diabetes. We tested whether this variant modified the effect of metformin in the Diabetes Prevention Program (DPP), in which metformin reduced diabetes incidence by 31% in volunteers with impaired glucose tolerance. RESEARCH...
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