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Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes.

Pharmacogenetics and genomics - 1 Feb 2022

Chen Peixian, Cao Yumin, Guo Yali, Xu Qi, Wang Xiaozhu, Zhang Liuwei, Liu Zhike, Chen Dafang, Chen Shiyi, Chen Shenren

Abstract excerpt

Metformin is the first-choice oral anti-hyperglycemic drug for type 2 diabetes mellitus (T2DM) patients. There are controversies about the association of SLC22A1 rs622342, which was not reported in the Chinese population, and ataxia-telangiectasia mutated (ATM) rs11212617 polymorphisms with metformin efficacy in T2DM. Our study was to investigate the effects of the two single nucleotide polymorphisms on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34545025
DOI: 10.1097/FPC.0000000000000454

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