Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.

doi:10.1111/hiv.12000

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Article

Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.

HIV medicine - 1 Apr 2013

Joven J, Menéndez J A, Fernandez-Sender L, Espinel E, Rull A, Beltrán-Debón R, Rodríguez-Gallego E, Riera-Borrull M, Pedro-Botet J, Alonso-Villaverde C, Camps J, Aragonès G

Abstract excerpt

OBJECTIVES: Insulin resistance in viral infections is common. We have explored the effectiveness of metformin for alleviating insulin resistance in HIV-infected patients and assessed the relevance of the ataxia-telangiectasia mutated (ATM) rs11212617 variant in the clinical response with the rationale that metformin modulates cellular bioenergetics in an ATM-dependent process. METHODS: HIV-infected patients (n =...

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PMID: 23171036
DOI: 10.1111/hiv.12000

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