Article
A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
Diabetologia - 1 Jul 2012
van Leeuwen N, Nijpels G, Becker M L, Deshmukh H, Zhou K, Stricker B H C, Uitterlinden A G, Hofman A, van 't Riet E, Palmer C N A, Guigas B, Slagboom P E, Durrington P, Calle R A, Neil A, Hitman G, Livingstone S J, Colhoun H, Holman R R, McCarthy M I, Dekker J M, 't Hart L M, Pearson E R
Abstract excerpt
AIMS/HYPOTHESIS: In this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the SNP rs11212617 at a locus that includes the ataxia telangiectasia mutated (ATM) gene in multiple additional populations. METHODS: Incident users of metformin selected from the Diabetes Care System West-Friesland (DCS, n = 929) and the Rotterdam Study (n = 182) from the...
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