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Article

A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT.

Pharmacogenomics - 1 Jun 2018

Out Mattijs, Becker Matthijs L, van Schaik Ron H, Lehert Philippe, Stehouwer Coen D, Kooy Adriaan

Abstract excerpt

AIM: To determine the influence of polymorphisms on the effects of metformin on HbA1c, daily dose of insulin and metformin plasma concentration. Methods: In a post hoc analysis of a 4.3 year placebo-controlled randomized trial with 390 patients with Type 2 diabetes already on insulin, we analyzed the influence of polymorphisms in genes coding for ATM and the transporters OCT1 and MATE1. Outcome measures were a...

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Source

Identifiers

PMID: 29790415
DOI: 10.2217/pgs-2018-0010

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT.PMID 29790415Read ↗

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