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Article

BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib.

Biochemical and biophysical research communications - 22 Jan 2017

Nagasawa Ikuko, Kunimasa Kazuhiro, Tsukahara Satomi, Tomida Akihiro

Abstract excerpt

In BRAF-mutated melanoma cells, the BRAF inhibitor, vemurafenib, induces phosphorylation of eukaryotic initiation factor 2α (eIF2α) and subsequent induction of activating transcription factor 4 (ATF4), the central regulation node of the integrated stress response (ISR). While the ISR supports cellular adaptation to various stresses, the role of vemurafenib-triggered ISR has not been fully characterized. Here, we...

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Source

Identifiers

PMID: 27965097
DOI: 10.1016/j.bbrc.2016.12.062

Genes

BRAF
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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