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Article

Rb1/105 gene alterations and head and neck carcinogenesis.

Molecular biology reports - 1 Oct 2012

Sabir Maimoona, Baig Ruqia Mehmood, Mahjabeen Ishrat, Saeed Muhammad, Malik Faraz Arshad, Kayani Mahmood Akhtar

Abstract excerpt

Retinoblastoma gene (Rb1) is a tumor suppressor gene, which plays a pivotal role in cell cycle regulation, promoting G1/S arrest and growth restriction through inhibition of the E2F transcription factor. Abnormalities in the genes involved in cell cycle, including Rb1, have been reported in head and neck cancer (HNC) patients. Studies regarding Rb1 have been observed in different world populations but data is...

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PMID: 22744425
DOI: 10.1007/s11033-012-1822-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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