Article
Differential alterations of the genes in the CDKN2A-CCND1-CDK4-RB1 pathway are associated with the development of head and neck squamous cell carcinoma in Indian patients.
Journal of cancer research and clinical oncology - 1 Nov 2003
Tripathi Bhar Anusri, Banerjee Soma, Chunder Neelanjana, Roy Anup, Sengupta Arunava, Roy Bidyut, Roychowdhury Susanta, Panda Chinmay Kumar
Abstract excerpt
PURPOSE: The aim of this study was to analyse the alterations of the genes in the CDKN2A/CCND1/CDK4/RB1 pathway in the G1-S phase of the cell cycle during development of head and neck squamous cell carcinoma (HNSCC). METHODS: The alterations of these genes were analysed in 22 dysplastic lesions, 26 stage-I/II and 33 stage-III/IV HNSCC tumours of Indian patients. RESULTS: The alterations [mutation,...
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