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Article

Importance of local hypoxia on endothelial phenotype for an in vitro approach to bone marrow angiogenesis.

Leukemia research - 1 Sept 2012

Gouel Flore, Kamanzi Sophie, Corbière Cécile, Buquet Catherine, Legrand Elisabeth, Vannier Jean-Pierre, Mulder Paul, Vasse Marc, Dubus Isabelle

Abstract excerpt

The vasculature of bone marrow differs from that in other organs, and its characteristics should be considered when exploring the medullar angiogenesis associated with hematological malignancies. We show here that the human bone marrow sinusoidal cell line HBME-1 has a specific expression pattern of angiogenic factors and receptors, characterized by a unique VEGFR3(+), Tie2(-) signature, that resembles the in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22742817
DOI: 10.1016/j.leukres.2012.05.026

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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