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Article

O2 level controls hematopoietic circulating progenitor cells differentiation into endothelial or smooth muscle cells.

PloS one - 1 Jan 2009

Berthelemy Nicolas, Kerdjoudj Halima, Schaaf Pierre, Prin-Mathieu Christine, Lacolley Patrick, Stoltz Jean-François, Voegel Jean-Claude, Menu Patrick

Abstract excerpt

BACKGROUND: Recent studies showed that progenitor cells could differentiate into mature vascular cells. The main physiological factors implicated in cell differentiation are specific growth factors. We hypothesized that simply by varying the oxygen content, progenitor cells can be differentiated either in mature endothelial cells (ECs) or contractile smooth muscle cells (SMCs) while keeping exactly the same...

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Identifiers

PMID: 19436758
DOI: 10.1371/journal.pone.0005514
PMCID: PMC2678195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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