Article
Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.
Molecular endocrinology (Baltimore, Md.) - 1 May 1990
Rundlett S E, Wu X P, Miesfeld R L
Abstract excerpt
In an effort to understand the molecular basis of androgen action in the prostate, we isolated androgen receptor (AR) cDNA from rat ventral prostate cells and analyzed the transcriptional regulatory activity of the encoded protein in a cotransfection assay. We found that AR is capable of inducing chloramphenicol acetyltransferase activity more than 20-fold using the mouse mammary tumor virus LTR as a source of...
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