Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.

doi:10.1210/mend-4-5-708

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Article

Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.

Molecular endocrinology (Baltimore, Md.) - 1 May 1990

Rundlett S E, Wu X P, Miesfeld R L

Abstract excerpt

In an effort to understand the molecular basis of androgen action in the prostate, we isolated androgen receptor (AR) cDNA from rat ventral prostate cells and analyzed the transcriptional regulatory activity of the encoded protein in a cotransfection assay. We found that AR is capable of inducing...

Topics

Androgens
Animals
DNA
Male
Molecular Biology
Mutation
Prostate
Rats
Receptors, Androgen
Receptors, Glucocorticoid
Recombinant Fusion Proteins
Transcription, Genetic

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