Article
Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 1997
Yen P M, Liu Y, Palvimo J J, Trifiro M, Whang J, Pinsky L, Jänne O A, Chin W W
Abstract excerpt
Androgen, glucocorticoid, and progesterone receptors (ARs, GRs, and PRs) often can regulate transcription via composite hormone response elements in target genes. We have used artificial and natural mutant ARs from patients with androgen resistance to study their effects on dominant negative acti...
Topics
- Androgens
- Animals
- Drug Resistance
- Humans
- Mammary Tumor Virus, Mouse
- Mutation
- Promoter Regions, Genetic
- Receptors, Androgen
- Receptors, Glucocorticoid
- Receptors, Progesterone
- Sequence Deletion
- Testosterone
- Transcription, Genetic
- Transfection