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Article

The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element

1 Dec 1991

Abstract excerpt

Expression of prostate-specific antigen (PA) mRNA was tested at various time periods after incubation of the human prostate tumor cell line LNCaP with the synthetic androgen R1881. Androgen-stimulated expression was observed within 6 h after addition of R1881 to the cells. Run-on experiments with nuclei isolated from LNCaP cells showed that expression of the PA gene could be regulated by R1881 on the level of...

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Identifiers

PMID: 1724287
DOI: 10.1210/mend-5-12-1921

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive ElementPMID 1724287Read ↗

An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter.Semantic proximity Read ↗

Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter.Semantic proximity Read ↗

Prostate-specific Antigen Expression Is Regulated by an Upstream EnhancerSemantic proximity Read ↗

Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation.Semantic proximity Read ↗

Cooperative Assembly of Androgen Receptor into a Nucleoprotein Complex That Regulates the Prostate-specific Antigen EnhancerSemantic proximity Read ↗

Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene.Semantic proximity Read ↗

Identification of 3',5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter.Semantic proximity Read ↗

The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens.Semantic proximity Read ↗

Human Androgen Receptor Binding to the Androgen Response Element of Prostate Specific AntigenSemantic proximity Read ↗

Transcriptional activation and nuclear targeting signals of the human androgen receptor.Semantic proximity Read ↗

Identification of Two Transcription Activation Units in the N-terminal Domain of the Human Androgen ReceptorSemantic proximity Read ↗

Identification of an androgen-dependent enhancer within the prostate stem cell antigen gene.Semantic proximity Read ↗

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