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Article

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

28 May 1996

Abstract excerpt

The androgen receptor (AR) is a member of the steroid receptor superfamily that plays an important role in male sexual differentiation and prostate cell proliferation. Mutations or abnormal expression of AR in prostate cancer can play a key role in the process that changes prostate cancer from androgen-dependent to an androgen-independent stage. Using a yeast two-hybrid system, we were able to isolate a...

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Share to Estrogen and related hormone effects
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Share to Prostate Cancer Treatment and Research

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Identifiers

PMID: 8643607
DOI: 10.1073/pnas.93.11.5517

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Related research

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Research trail→

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Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.PMID 8643607Read ↗

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From estrogen to androgen receptor: A new pathway for sex hormones in prostateSemantic proximity Read ↗

Functional Domain and Motif Analyses of Androgen Receptor Coregulator ARA70 and Its Differential Expression in Prostate CancerSemantic proximity Read ↗

A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth.Semantic proximity Read ↗

Minireview: Alternative activation pathways for the androgen receptor in prostate cancer.Semantic proximity Read ↗

Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional ComplexSemantic proximity Read ↗

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