Article
Testing drug response in the presence of genetic information: sampling issues for clinical trials.
Pharmacogenetics - 1 Aug 2000
Cardon L R, Idury R M, Harris T J, Witte J S, Elston R C
Abstract excerpt
Progress towards construction of a dense map of di-allelic markers across the human genome has generated considerable enthusiasm for pharmacogenomic applications. To date, however, nearly all of the effort on single nucleotide polymorphism (SNP) projects has been focused on marker identification and screening, not on how the SNP genotype data actually can be used in clinical trials to advance medical practice....
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