Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness

6 Nov 2018

Abstract excerpt

Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear genome, and anterograde signalling to mitochondria. All these interactions have the potential to alter the frequencies of mtDNA haplotypes (mitotypes) in nature and may impact human health. In a model laboratory system, we fed four...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Metabolism and Genetic Disorders
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30399141
DOI: 10.1371/journal.pgen.1007735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitnessPMID 30399141Read ↗

Drosophila mitotypes determine developmental time in a diet and temperature dependent manner.Semantic proximity Read ↗

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel.Semantic proximity Read ↗

Mitonuclear interactions modulate nutritional preference.Semantic proximity Read ↗

Mitonuclear interactions shape both direct and parental effects of diet on fitness and involve a SNP in mitoribosomal 16s rRNA.Semantic proximity Read ↗

G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.Semantic proximity Read ↗

Towards understanding the evolutionary dynamics of mtDNA.Semantic proximity Read ↗

Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axisSemantic proximity Read ↗

Systems biology and machine learning approaches identify metabolites that influence dietary lifespan and healthspan responses across flies and humansSemantic proximity Read ↗

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing.Semantic proximity Read ↗

Yin and Yang of mitochondrial ROS in Drosophila.Semantic proximity Read ↗

Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.Semantic proximity Read ↗

Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.