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Article

Mitochondrial genotype modulates mtDNA copy number and organismal phenotype in Drosophila.

Mitochondrion - 1 May 2017

Salminen Tiina S, Oliveira Marcos T, Cannino Giuseppe, Lillsunde Päivi, Jacobs Howard T, Kaguni Laurie S

Abstract excerpt

We evaluated the role of natural mitochondrial DNA (mtDNA) variation on mtDNA copy number, biochemical features and life history traits in Drosophila cybrid strains. We demonstrate the effects of both coding region and non-coding A+T region variation on mtDNA copy number, and demonstrate that copy number correlates with mitochondrial biochemistry and metabolically important traits such as development time. For...

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PMID: 28214560
DOI: 10.1016/j.mito.2017.02.001

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