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Article

Residues at the outer mouth of Kir1.1 determine K-dependent gating.

Biophysical journal - 20 Jun 2012

Sackin Henry, Nanazashvili Mikheil, Li Hui, Palmer Lawrence G, Yang Lei

Abstract excerpt

Three residues (E132, F127, and R128) at the outer mouth of Kir1.1b directly affected inward rectifier gating by external K, independent of pH gating. Each of the individual mutations E132Q, F127V, F127D, and R128Y changed the normal K dependence of macroscopic conductance from hyperbolic (Km = 6 ± 2 mM) to linear, up to 500 mM, without changing the hyperbolic K dependence of single-channel conductance. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22735524
DOI: 10.1016/j.bpj.2012.05.018
PMCID: PMC3379619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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