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Article

Modulation of aggregation and structural polymorphisms of β-amyloid fibrils in cellular environments by pyroglutamate-3 variant cross-seeding

24 Aug 2023

Abstract excerpt

Amyloidogenic deposition of β-amyloid (Aβ) peptides in human brain involves not only the wild-type Aβ (wt-Aβ) sequences, but also a heterogeneous pool of post-translationally modified Aβ (PTM-Aβ) variants. Recent studies raise a hypothesis that the PTM-Aβ variants may trigger the deposition of wt-Aβ, which may underlie the pathology of sporadic Alzheimer's disease (sAD). Among all PTM-Aβ variants, the...

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PMID: 37633335
DOI: 10.1016/j.jbc.2023.105196

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