RelB/NF-κB2 Regulates Corticotropin-Releasing Hormone in the Human Placenta

doi:10.1210/me.2012-1035

Article

RelB/NF-κB2 Regulates Corticotropin-Releasing Hormone in the Human Placenta

27 Jun 2012

Abstract excerpt

Placental CRH may be part of a clock that governs the length of human gestation. The mechanism underlying differential regulation of CRH in the human placenta is poorly understood. We report here that constitutively activated RelB/nuclear factor-κB2 (NF-κB)-2 (p100/p52) acts as an endogenous stimulatory signal to regulate CRH by binding to an NF-κB enhancer of CRH gene promoter in the human placenta. Nuclear...

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