Article
Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2004
van de Stolpe Anja, Slycke Annika J, Reinders Marjolein O, Zomer Anna W M, Goodenough Sharon, Behl Christian, Seasholtz Audrey F, van der Saag Paul T
Abstract excerpt
CRH-binding protein (CRH-BP) regulates activation of the hypothalamic-pituitary-adrenal (HPA) axis by binding and inhibiting CRH. We investigated for the first time transcriptional regulation of the human CRH-BP promoter using transient transfections. Estrogen receptors (ERs) contributed to ligan...
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