Article
The human placenta and fetal membranes express the corticotropin-releasing hormone receptor 1alpha (CRH-1alpha) and the CRH-C variant receptor.
The Journal of clinical endocrinology and metabolism - 1 Apr 1998
Karteris E, Grammatopoulos D, Dai Y, Olah K B, Ghobara T B, Easton A, Hillhouse E W
Abstract excerpt
Placentally derived CRH plays a major role in the mechanisms controlling human pregnancy and parturition. It has been suggested that there is a CRH placental clock that is active from the early stages of pregnancy and determines the length of gestation and the timing of parturition. CRH can influ...
Topics
- Extraembryonic Membranes
- Female
- Fluorescent Antibody Technique
- Genetic Variation
- Humans
- In Situ Hybridization, Fluorescence
- Placenta
- Polymerase Chain Reaction
- Pregnancy
- Receptors, Corticotropin-Releasing Hormone
- Sequence Analysis, DNA