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Article

Mono-(2-Ethylhexyl) Phthalate Promotes Pro-Labor Gene Expression in the Human Placenta

11 Jan 2016

Abstract excerpt

Women exposed to phthalates during pregnancy are at increased risk for delivering preterm, but the mechanism behind this relationship is unknown. Placental corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2) are key mediators of parturition and are regulated by the non-canonical NF-kB (RelB/p52) signaling pathway. In this study, we demonstrate that one of the major phthalate metabolites,...

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PMID: 26751383
DOI: 10.1371/journal.pone.0147013

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Mono-(2-Ethylhexyl) Phthalate Promotes Pro-Labor Gene Expression in the Human PlacentaPMID 26751383Read ↗

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