Expression and Deoxyribonucleic Acid-Binding Activity of the Nuclear Factor κB Family in the Human Myometrium during Pregnancy and Labor

Abstract excerpt

In humans, the factors that govern the switch from myometrial quiescence to coordinated contractions at the initiation of labor are not well defined. The onset of parturition is itself associated with increases in a number of proinflammatory factors, many of which are regulated by the nuclear factor kappaB (NF-kappaB) family of transcription factors. The expression and DNA-binding activity of NF-kappaB in the...

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