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Article

Tumor heterogeneity and personalized cancer medicine: are we being outnumbered?

Future oncology (London, England) - 1 Feb 2014

Cirkel Geert A, Gadellaa-van Hooijdonk Christa G, Koudijs Marco J, Willems Stefan M, Voest Emile E

Abstract excerpt

Tumor heterogeneity is regarded as a major obstacle to successful personalized cancer medicine. The lack of reliable response assays reflective of in vivo tumor heterogeneity and associated resistance mechanisms hampers identification of reliable biomarkers. By contrast, oncogene addiction and paracrine signaling enable systemic responses despite tumor heterogeneity. This strengthens researchers in their efforts...

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Identifiers

PMID: 24559448
DOI: 10.2217/fon.13.214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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