Article
ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization.
Allergology international : official journal of the Japanese Society of Allergology - 1 Jan 2021
Kitazawa Haruna, Masuko Hironori, Kanazawa Jun, Shigemasa Rie, Hyodo Kentaro, Yamada Hideyasu, Yatagai Yohei, Kaneko Yoshiko, Iijima Hiroaki, Naito Takashi, Saito Takefumi, Noguchi Emiko, Konno Satoshi, Hirota Tomomitsu, Tamari Mayumi, Sakamoto Tohru, Hizawa Nobuyuki
Abstract excerpt
BACKGROUND: An orosomucoid-like 3 (ORMDL3)/gasdermin B (GSDMB) gene locus on chromosome 17q is consistently associated with childhood-onset asthma, which is highly atopic. As some evidence suggests the relationship between asthma and allergic sensitization reflects asthma patient susceptibility to augmented IgE responses driven by common environmental allergens rather than an increased asthma risk after allergen...
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