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The wobble nucleotide-excising anticodon nuclease RloC is governed by the zinc-hook and DNA-dependent ATPase of its Rad50-like region.

Nucleic acids research - 1 Sept 2012

Klaiman Daniel, Steinfels-Kohn Emmanuelle, Krutkina Ekaterina, Davidov Elena, Kaufmann Gabriel

Abstract excerpt

The conserved bacterial anticodon nuclease (ACNase) RloC and its phage-excluding homolog PrrC comprise respective ABC-adenosine triphosphatase (ATPase) and ACNase N- and C-domains but differ in three key attributes. First, prrC is always linked to an ACNase silencing, DNA restriction-modification (R-M) locus while rloC rarely features such linkage. Second, RloC excises its substrate's wobble nucleotide, a lesion...

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PMID: 22730290
DOI: 10.1093/nar/gks593
PMCID: PMC3458546

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Source receipt: pubmed, retrieved 7 Sept 2026.

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