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Article

DNA repair defects sensitize cells to anticodon nuclease yeast killer toxins.

Molecular genetics and genomics : MGG - 1 Mar 2011

Klassen Roland, Wemhoff Sabrina, Krause Jens, Meinhardt Friedhelm

Abstract excerpt

Killer toxins from Kluyveromyces lactis (zymocin) and Pichia acaciae (PaT) were found to disable translation in target cells by virtue of anticodon nuclease (ACNase) activities on tRNA(Glu) and tRNA(Gln), respectively. Surprisingly, however, ACNase exposure does not only impair translation, but also affects genome integrity and concomitantly DNA damage occurs. Previously, it was shown that homologous...

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Identifiers

PMID: 21188417
DOI: 10.1007/s00438-010-0597-5

Genes

ELP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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